Ritvo R, Monroe P, Andriole V T
Yale J Biol Med. 1977 Sep-Oct;50(5):471-9.
The incidence and character of the bacteremia associated with elective suction abortion was investigated in volunteer subjects aged 19 to 35 years who were to undergo first trimester abortion by suction curettage. One hundred and forty-four blood cultures were obtained from thirteen pregnant and four non-pregnant (control) subjects matched for age. Transient bacteremia occurred during or soon after suction abortion in 11 of 13 (84.7%) study subjects. Four of these patients were bacteremic after bimanual pelvic examination, just prior to initiation of the abortion procedure. Seven others developed bacteremia temporally related to cervical dilatation and suction abortion. The bacteremia was intermittent in some, persistent in others, existed as long as one hour after the procedure, and was transient in all patients. Microorganisms isolated from the blood were all normal genital tract flora and were predominantly anaerobes, although alpha hemolytic streptococci were also recovered. Mixed bacteremia occurred in six patients. In contrast, blood cultures from four non-pregnant women were sterile. This study indicates that the systemic circulation-uterine cavity barrier is significantly disrupted during abortion by suction curettage permitting endogenous genital tract microorganisms to gain access into the bloodstream. These observations also suggest that there may be some risk of developing endocarditis during suction abortion in patients with cardiac deformities, and lend some support to the current practice of giving antibiotic prophylaxis to abortion patients with cardiac lesions which predispose them to endocarditis.
对年龄在19至35岁、计划通过刮宫术进行早期妊娠流产的志愿者进行研究,以调查与选择性人工流产相关的菌血症的发生率和特征。从13名孕妇和4名年龄匹配的非孕妇(对照组)身上采集了144份血培养样本。13名研究对象中有11名(84.7%)在人工流产期间或之后不久出现短暂菌血症。其中4名患者在双合诊盆腔检查后、人工流产手术开始前即出现菌血症。另外7名患者的菌血症与宫颈扩张和人工流产在时间上相关。菌血症在一些患者中呈间歇性,在另一些患者中持续存在,术后长达1小时,且所有患者的菌血症均为短暂性。从血液中分离出的微生物均为正常生殖道菌群,以厌氧菌为主,不过也分离出了α溶血性链球菌。6名患者出现混合菌血症。相比之下,4名非孕妇的血培养结果无菌。本研究表明,刮宫术人工流产期间,体循环-子宫腔屏障被显著破坏,使得内源性生殖道微生物得以进入血流。这些观察结果还表明,心脏畸形患者在人工流产期间可能有发生心内膜炎的风险,并支持目前对有易患心内膜炎心脏病变的流产患者给予抗生素预防的做法。