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发育中大脑的蛋白质代谢:出生及胎龄的影响

Protein metabolism in the developing brain: influence of birth and gestational age.

作者信息

Schain R J, Carver M J, Copenhaver J H, Underdahl N R

出版信息

Science. 1967 May 19;156(3777):984-6. doi: 10.1126/science.156.3777.984.

DOI:10.1126/science.156.3777.984
PMID:6023271
Abstract

Incorporation of carbon-14-labeled phenylalanine into brain protein of newborn pigs falls sharply within 24 hours after birth. This decrease is related to the time of birth rather than the gestational age of the piglets, although the latter is also associated with a gradual decrease in brain protein synthesis.

摘要

新生猪脑中碳-14标记的苯丙氨酸掺入量在出生后24小时内急剧下降。这种下降与出生时间有关,而非仔猪的胎龄,尽管胎龄也与脑蛋白合成的逐渐减少有关。

相似文献

1
Protein metabolism in the developing brain: influence of birth and gestational age.发育中大脑的蛋白质代谢:出生及胎龄的影响
Science. 1967 May 19;156(3777):984-6. doi: 10.1126/science.156.3777.984.
2
Postnatal changes in protein metabolism of brain. I. Studies in newborn miniature pigs at varying conceptual ages.
Pediatr Res. 1969 Mar;3(2):135-9. doi: 10.1203/00006450-196903000-00005.
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Protein synthesis in the brain of rats thyroidectomized at birth.出生时甲状腺切除的大鼠大脑中的蛋白质合成。
Experientia. 1968 Jul 15;24(7):677-8. doi: 10.1007/BF02138307.
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Elevated plasma phenylalanine concentration and lysine incorporation into ribosomal protein of developing brain.
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Fetal development: the effects of maturation on in vitro protein synthesis by mouse brain tissue.胎儿发育:成熟对小鼠脑组织体外蛋白质合成的影响。
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Effect of excess methionine administration on protein synthesis in developing rat brain.
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Protein synthesis in liver and brain microsomes isolated from rats fed a high phenylalanine diet.从喂食高苯丙氨酸饮食的大鼠中分离出的肝脏和脑微粒体中的蛋白质合成。
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Developmental changes in aminoacylation of mouse brain tRNa.小鼠脑转运RNA氨酰化的发育变化
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Precursor and age-dependent differences in in vivo rates of protein synthesis in the cerebral cortex.大脑皮质中蛋白质合成的体内速率的前体和年龄依赖性差异。
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Incorporation of phenylalanine, tyrosine and tryptophan into protein of homogenates from developing rat brain: kinetics of incorporation and reciprocal inhibition.苯丙氨酸、酪氨酸和色氨酸掺入发育中大鼠脑匀浆蛋白质的情况:掺入动力学及相互抑制作用
J Neurochem. 1972 Sep;19(9):2057-69. doi: 10.1111/j.1471-4159.1972.tb05116.x.

引用本文的文献

1
Neuron-specific aminopeptidase and puromycin-sensitive aminopeptidase in rat brain development.大鼠脑发育过程中的神经元特异性氨肽酶和嘌呤霉素敏感性氨肽酶
Neurochem Res. 2003 Jun;28(6):855-60. doi: 10.1023/a:1023263123911.
2
Development of the metanephric kidney. Protein and nucleic acid synthesis.后肾的发育。蛋白质和核酸合成。
J Cell Biol. 1968 Jun;37(3):703-15. doi: 10.1083/jcb.37.3.703.
3
Protein synthesis by astrocytes in primary cultures.原代培养星形胶质细胞的蛋白质合成
Neurochem Res. 1981 Apr;6(4):353-64. doi: 10.1007/BF00963850.
4
Segmental incorporation of [3H]leucine in the rat spinal cord. Is the protein metabolism of nerve cells related to the size of their axons.大鼠脊髓中[3H]亮氨酸的节段性掺入。神经细胞的蛋白质代谢与其轴突大小有关吗?
J Anat. 1969 Jul;105(Pt 1):47-57.