Tormey D C, Kamin R, Fudenberg H H
J Exp Med. 1967 May 1;125(5):863-72. doi: 10.1084/jem.125.5.863.
Leukocytes from nine patients with acquired agammaglobulinemia were studied in vitro. Synthesis of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) induced by phytohemagglutinin was measured by determination of the degree of incorporation of labeled precursor. Synthesis of both DNA and RNA was decreased in the agammaglobulinemic cells. The presence of an inhibitor in the patients' sera could not be demonstrated. These results suggest that the basic defect in agammaglobulinemia is cellular rather than humoral.
对9例获得性无丙种球蛋白血症患者的白细胞进行了体外研究。通过测定标记前体的掺入程度来检测植物血凝素诱导的脱氧核糖核酸(DNA)和核糖核酸(RNA)的合成。无丙种球蛋白血症细胞中DNA和RNA的合成均减少。未证实患者血清中存在抑制剂。这些结果表明,无丙种球蛋白血症的基本缺陷是细胞性的而非体液性的。