Mehra V L, Talwar G P, Balakrishnan K, Bhutani L K
Clin Exp Immunol. 1972 Oct;12(2):205-13.
Mitogenic response to phytohaemagglutinin (PHA) of peripheral leucocytes from patients with polar forms of leprosy namely lepromatous leprosy (LL) and tuberculoid leprosy (TT) has been evaluated. No defect in blast transformation as assessed by the incorporation of H-thymidine into DNA was observed in tuberculoid leprosy patients. In lepromatous leprosy patients, the response varied with the status of the patient. Leucocytes from untreated cases of lepromatous leprosy showed a depressed response to PHA, whereas the leucocytes from patients treated with diaminodiphenylsulphone (DDS) gave an enhanced response. While the functional deficit was manifest in cells, the plasma factors were found to be contributory agents to the type of response elicited. Factors influencing the transformation of peripheral leucocytes have also been studied.
对麻风两极型患者，即瘤型麻风（LL）和结核样型麻风（TT）外周血白细胞对植物血凝素（PHA）的促有丝分裂反应进行了评估。在结核样型麻风患者中，未观察到通过将³H-胸腺嘧啶核苷掺入DNA评估的母细胞转化缺陷。在瘤型麻风患者中，反应因患者状况而异。未经治疗的瘤型麻风病例的白细胞对PHA的反应降低，而用二氨基二苯砜（DDS）治疗的患者的白细胞反应增强。虽然功能缺陷在细胞中表现明显，但发现血浆因子是引发反应类型的促成因素。还研究了影响外周血白细胞转化的因素。
