[肌萎缩侧索硬化症病理过程的主要定位]
[Primary localization of the pathologic process in amyotrophic lateral sclerosis].
作者信息
Zavalishin I A, Shaposhnikov E A
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(12):1761-5.
PMID:602549
Abstract
The clinico-electromyographical study was conducted in 120 patients with motor disturbances in amyotrophical lateral sclerosis. Comparing the clinical and electromyographical data in different variants of this disease the authors make a conclusion on the simultaneous damage of peripheral and central mononeurons from the very onset of the disease. Along with this the latter is damaged not only primarily, but secondarily as a result of trans-synaptic degerneration due to pathology of the segmental-nucleus motor cells.
摘要
对120例肌萎缩侧索硬化症运动障碍患者进行了临床肌电图研究。通过比较该疾病不同变体的临床和肌电图数据，作者得出结论，从疾病一开始，外周和中枢单神经元就同时受到损害。与此同时，后者不仅主要受到损害，还会由于节段性核运动细胞的病理变化导致的跨突触变性而继发受损。
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