Jonsson A, Wales J K
Diabetologia. 1976 Jul;12(3):245-50. doi: 10.1007/BF00422091.
Five glycoproteins have been measured in the blood of 145 diabetic patients with and without clinical evidence of complications. Patients with diabetic complications have higher glycoproteins levels particularly when expressed as a ratio to serum albumin levels. In 32 pairs of patients matched for age, sex, body weight, duration and treatment of diabetes, significantly higher haptoglobin, fibrinogen and caeruloplasmin levels were associated with the presence of diabetic complications, but blood glucose levels were not significantly different. Beta-lipoprotein levels were positively correlated with age and alpha2-macroglobulin levels with the duration of clinical disease, but the type of antidiabetic therapy administered did not significantly alter glycoprotein levels. It is suggested that rising levels of certain glycoproteins in the blood of diabetic patients may indicate the development of diabetic vascular complications, but a prospective study is required before it can be decided whether this change predates the clinical appearance of the complications.
对145例有或无并发症临床证据的糖尿病患者的血液进行了5种糖蛋白的检测。有糖尿病并发症的患者糖蛋白水平较高，尤其是以与血清白蛋白水平的比值表示时。在32对年龄、性别、体重、糖尿病病程和治疗相匹配的患者中，触珠蛋白、纤维蛋白原和铜蓝蛋白水平显著升高与糖尿病并发症的存在相关，但血糖水平无显著差异。β-脂蛋白水平与年龄呈正相关，α2-巨球蛋白水平与临床疾病病程呈正相关，但所采用的抗糖尿病治疗类型并未显著改变糖蛋白水平。提示糖尿病患者血液中某些糖蛋白水平升高可能表明糖尿病血管并发症的发生，但在确定这种变化是否早于并发症的临床出现之前，还需要进行前瞻性研究。
