长春碱在体外对微管装配的抑制作用。
Vinblastine inhibition of microtubule assembly in vitro.
作者信息
Sajó I
出版信息
Acta Biochim Biophys Acad Sci Hung. 1977;12(3):259-61.
PMID:602674
Abstract
The effect of vinblastine on the in vitro polymerization of tubulin was investigated. It has been shown that the presence of VLB prevents the assembly of tubulin in rat brain extracts, and the addition of VLB to assembled microtubules results in their rapid depolymerization. The polymerization was monitored by viscometry and electron microscopy.
摘要
研究了长春花碱对微管蛋白体外聚合的影响。已表明长春花碱的存在会阻止大鼠脑提取物中微管蛋白的组装，并且向已组装的微管中添加长春花碱会导致它们迅速解聚。通过粘度测定法和电子显微镜监测聚合过程。
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