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Studies on morphine tolerance in mice. I. In vivo N-demethylation of morphine and N- and O-demethylation of codeine.

作者信息

Adler T K

出版信息

J Pharmacol Exp Ther. 1967 Jun;156(3):585-90.

PMID:6028882
Abstract
摘要

相似文献

1
Studies on morphine tolerance in mice. I. In vivo N-demethylation of morphine and N- and O-demethylation of codeine.小鼠吗啡耐受性的研究。I. 吗啡的体内N-去甲基化及可待因的N-和O-去甲基化
J Pharmacol Exp Ther. 1967 Jun;156(3):585-90.
2
N-demethylation of N-14C-methyl-codeine in morphine tolerant and nontolerant rats and mice.吗啡耐受和非耐受大鼠及小鼠体内N-14C-甲基可待因的N-去甲基化作用
Proc Soc Exp Biol Med. 1971 Mar;136(3):782-4. doi: 10.3181/00379727-136-35364.
3
Antemortem conversion of codeine to morphine in man.
J Forensic Sci. 1976 Jul;21(3):518-24.
4
Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.CYP2D6(异喹胍/司巴丁)基因多态性的慢代谢型和快代谢型人群中的内源性可待因和吗啡
J Pharmacol Exp Ther. 1994 Feb;268(2):546-51.
5
Codeine analgesia is due to codeine-6-glucuronide, not morphine.可待因镇痛作用是由可待因 - 6 - 葡萄糖醛酸苷引起的,而非吗啡。
Int J Clin Pract. 2000 Jul-Aug;54(6):395-8.
6
A chromatographic investigation of morphine metabolism in rats. Confirmation of N-demethylation of morphine and isolation of a new metabolite.大鼠体内吗啡代谢的色谱研究。吗啡N-去甲基化的确认及一种新代谢物的分离。
Drug Metab Dispos. 1974 Jan-Feb;2(1):23-30.
7
Morphine and codeine. The analgesic effect in tolerant and non-tolerant rats.
Acta Pharmacol Toxicol (Copenh). 1967;25:Suppl 3:3-83.
8
Specific radioimmunoassays for codeine and morphine. Metabolism of codeine to morphine in the rat.
Res Commun Chem Pathol Pharmacol. 1977 Aug;17(4):595-603.
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The effect of tolerance and withdrawal on the in vivo metabolism of N-C14-methyl-dihydro-morphine in the rat.耐受性和戒断对大鼠体内N - C14 - 甲基 - 二氢吗啡代谢的影响。
J Pharmacol Exp Ther. 1969 Oct;169(2):168-74.
10
Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors.吗啡和可待因类似物对G蛋白的激活作用:对μ和δ阿片受体上O-去甲基化和N-去甲基化代谢产物相关性的见解
J Pharmacol Exp Ther. 2004 Feb;308(2):547-54. doi: 10.1124/jpet.103.058602. Epub 2003 Nov 4.

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A sex difference in the effect of phenazocine and dihydrocodeine on the blood pH of the unanaesthetized rabbit.非那佐辛和二氢可待因对未麻醉家兔血液pH值影响的性别差异。
Br J Pharmacol Chemother. 1968 Feb;32(2):253-61. doi: 10.1111/j.1476-5381.1968.tb00969.x.
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A study of the factors affecting the sleeping time following intracerebroventricular administration of pentobarbitone sodium: effect of prior administration of centrally active drugs.脑室内注射戊巴比妥钠后影响睡眠时间的因素研究:中枢活性药物预先给药的作用
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