Chugh K S, Singhal P C, Sharma B K, Mahakur A C, Pal Y, Datta B N, Das K C
Am J Med Sci. 1977 Sep-Oct;274(2):139-46. doi: 10.1097/00000441-197709000-00004.
Acute renal failure due to intravascular hemolysis is a common clinical problem in North Indian patients. It constituted 21.5 percent of 325 patients dialyzed for acute renal failure over an 11-year period at Chandigarh. Thirty patients had developed acute intravascular hemolysis in association with erythrocyte glucose-6 phosphate dehydrogenase (G-6PD) deficiency, 17 due to copper sulphate intoxication and 8 due to envenomation by snakes. Less frequent causes were insect stings, incompatible blood transfusion, intake of anti-leprosy drug--dapsone in non-G-6PD-deficient patients, and mercuric chloride toxicity in two patients each; naphthalene poisoning in one; and uncertain causes in six patients. Renal histology was available in 55 patients. Acute tubular necrosis was seen in 54 and bilateral diffuse cortical necrosis in one patient. Fifty patients (71.43 percent) survived and 20(28.6 percent) diet. G-6PD erythrocyte deficiency, which is present in 4.5 percent of the North Indian population, was the most frequent cause of acute renal failure in this group.
血管内溶血所致急性肾衰竭是北印度患者常见的临床问题。在昌迪加尔，11年间因急性肾衰竭接受透析的325例患者中，该病占21.5%。30例患者发生急性血管内溶血并伴有红细胞葡萄糖-6-磷酸脱氢酶（G-6PD）缺乏，17例因硫酸铜中毒，8例因蛇咬伤。较少见的病因有昆虫叮咬、输血不相容、非G-6PD缺乏患者摄入抗麻风药氨苯砜、2例患者汞氯化物中毒、1例萘中毒以及6例病因不明。55例患者有肾脏组织学检查结果。54例可见急性肾小管坏死，1例为双侧弥漫性皮质坏死。50例（71.43%）存活，20例（28.6%）死亡。G-6PD红细胞缺乏在北印度人群中占4.5%，是该组急性肾衰竭最常见的病因。
