大鼠体内反式视黄醇醋酸酯的代谢及生物学活性
Metabolism and biological potency of retro-retinyl acetate in the rat.
作者信息
John K V, Lakshmanan M R, Cama H R
出版信息
Biochem J. 1967 May;103(2):544-9. doi: 10.1042/bj1030544.
Abstract
- retro-Retinyl acetate was shown to exert its biological activity by conversion into vitamin A. 2. When administered orally, retro-retinyl acetate was hydrolysed to retro-retinol in the intestine, isomerized to retinol and esterified before being transported to the liver for storage. 3. Administration of the compound at as high a dose as 4.0mg./day for 4 days led to the accumulation of both vitamin A and retro-vitamin A in the liver. The amount of retro-vitamin A in liver gradually decreased until it was almost completely converted into vitamin A in 18 days. 4. Intraperitoneal administration of the compound led to the accumulation of both vitamin A and retro-vitamin A in liver and other tissues. No vitamin A was detected in any tissue of rats receiving retro-retinyl acetate intraperitoneally after enterectomy. 5. The small intestine is the major site of conversion of retro-vitamin A into vitamin A. The conversion could also be demonstrated by everted intestinal sacs. 6. The biological potency of retro-retinyl acetate determined by the rat-growth assay was 20.5% that of all-trans-retinyl acetate, when given orally.
摘要
- 反式视黄醇乙酸酯经转化为维生素A后发挥其生物活性。2. 口服时，反式视黄醇乙酸酯在肠道内水解为反式视黄醇，异构化为视黄醇并酯化，然后转运至肝脏储存。3. 以每天4.0毫克的高剂量给药该化合物4天，导致肝脏中维生素A和反式维生素A均蓄积。肝脏中反式维生素A的量逐渐减少，直至18天几乎完全转化为维生素A。4. 腹腔注射该化合物导致肝脏和其他组织中维生素A和反式维生素A均蓄积。肠切除术后腹腔注射反式视黄醇乙酸酯的大鼠的任何组织中均未检测到维生素A。5. 小肠是反式维生素A转化为维生素A的主要部位。外翻肠囊也可证明这种转化。6. 通过大鼠生长试验测定，口服时反式视黄醇乙酸酯的生物效价为全反式视黄醇乙酸酯的20.5%。
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