Scuvee-Moreau J, Lepot M, Brotchi J, Gerebtzoff M A, Dresse A
Arch Int Pharmacodyn Ther. 1977 Nov;230(1):92-9.
A semi-chronic model of cobalt-induced experimental epilepsy in the rat was used to investigate the action of two classic anticonvulsant drugs, phenytoin and ethosuximide. Single injections of ethosuximide lead to an inhibition of the epileptic discharges. We failed to demonstrate an inhibitory effect of phenytoin after preventive administration. The carbidopa-L-dopa association was investigated owing to the inhibitory effects of dopamine and its presence in the cortex. We showed that a dose of 100 mg/kg of L-dopa combined with 25 mg/kg of carbidopa is necessary and sufficient to produce an almost complete inhibition of the discharges.
采用大鼠钴诱导实验性癫痫的半慢性模型来研究两种经典抗惊厥药物苯妥英和乙琥胺的作用。单次注射乙琥胺可抑制癫痫放电。预防性给药后，我们未能证明苯妥英有抑制作用。由于多巴胺的抑制作用及其在皮质中的存在，对卡比多巴 - 左旋多巴联合用药进行了研究。我们发现，100 mg/kg的左旋多巴与25 mg/kg的卡比多巴联合使用，足以几乎完全抑制放电。
