Holm J
Arch Int Pharmacodyn Ther. 1977 Dec;230(2):180-9.
Exit of 14C-tetraethylammonium (TEA) was studied in mouse kidney cortex slices incubated in Krebs-Ringer bicarbonate buffer (37 degrees C, pH 7.4) aerated with O2-CO295:5 v/v%. Substitution of Na+ in the wash out buffer by K+, Rb+ or the organic cations TEA and choline resulted in a stimulation of exit which, however, may be secondary to concomitant biochemical changes in the tissue (increase of water content and relative loss of K+) seen in the presence of these cations. However, enhancement of 14C-TEA exit although less pronounced was also produced of low organic cation concentrations having no effect on tissue water and K+. The latter specific effect on 14C-TEA exit may represent an interaction phenomenon in renal organic cation transport of accelerative exchange diffusion type.
在以体积比95:5的O₂-CO₂进行通气的Krebs-林格碳酸氢盐缓冲液（37℃，pH 7.4）中孵育的小鼠肾皮质切片中，对¹⁴C-四乙铵（TEA）的排出进行了研究。用K⁺、Rb⁺或有机阳离子TEA和胆碱替代洗脱缓冲液中的Na⁺会导致排出增加，然而，这可能继发于在这些阳离子存在下观察到的组织中的伴随生化变化（含水量增加和K⁺相对丢失）。不过，低浓度有机阳离子虽对组织水和K⁺无影响，但也会使¹⁴C-TEA排出增加，尽管不太明显。后者对¹⁴C-TEA排出的特定作用可能代表了肾有机阳离子转运中加速交换扩散类型的一种相互作用现象。
