Vengerovskiĭ A I, Saratikov A S, Tikhonova N M
Arkh Patol. 1977;39(11):72-7.
Histochemical changes in the heart, liver and kidneys and ultrastructural disorders in cardiomyocytes were studied in 40 white rats with adjuvant disease. Mucoid lesions, hydropyc dystrophy and necribiosis of muscle cells developed in the heart, diffuse extra-intracapillary glomerulonephritis in combination with nephrosis in the kidneys. In the liver, dyscomplexation of hepatic trabeculas, distention of perisinusoidal spaces were observed; in hepatocytes, the processes of protein synthesis were activated, and signs of hydropyc dystrophy and necrobiosis developed. The activity of enzymes of the aerobic phase of energetic metabolism was reduced and that of lactate dehydrogenase and acid phosphatase increased in cardiomyocytes, hepatocytes, and epithelium of convoluted tubules of the kidneys. Mitochondria of cardiomyocytes were swollen, myofibrilles fragmented.
对40只患有佐剂病的白色大鼠的心脏、肝脏和肾脏的组织化学变化以及心肌细胞的超微结构紊乱进行了研究。心脏出现了肌肉细胞的黏液样病变、水样变性和坏死，肾脏出现弥漫性毛细血管内肾小球肾炎合并肾病。在肝脏中，观察到肝小梁结构紊乱、窦周间隙扩张；肝细胞中蛋白质合成过程被激活，出现水样变性和坏死的迹象。心肌细胞、肝细胞和肾曲管上皮细胞中能量代谢需氧相的酶活性降低，乳酸脱氢酶和酸性磷酸酶活性增加。心肌细胞的线粒体肿胀，肌原纤维断裂。
