Parr E L, Schaedler R W, Hirsch J G
J Exp Med. 1967 Sep 1;126(3):523-38. doi: 10.1084/jem.126.3.523.
A chronic infiltration of polymorphonuclear leukocytes was invariably found in the infertile regions of uteri containing foreign bodies in conventional rats, germfree rats, mice, and rabbits. Polymorphonuclear leukocytes were never found in the fertile regions of these uteri. A foreign body in the uterus of the rat, and probably also the mouse, was associated with a bacterial infection which spread the inflammatory response throughout the horn containing the foreign body, and in the mouse occasionally into the control horn as well. No bacteria could be cultured from the rabbit uterine horn containing a foreign body. In the germfree rat, both the infiltration of polymorphonuclear leukocytes into the uterus and fertility were significantly different from that observed in the conventional rat. Whereas in the conventional rat the inflammation and infertility extended along the entire length of the uterine horn containing a small foreign body, in the germfree rat the inflammation and infertility were closely correlated to the position of the foreign body. As judged by measurements of lysozyme in the uterine lumens of rats and rabbits, polymorphonuclear leukocytes released their contents into solution in the uterine lumen. It is concluded that some substance derived from polymorphonuclear leukocytes may exert toxic effects on fertilized ova or on spermatozoa and thus be responsible for the infertility of uteri containing foreign bodies.
在常规大鼠、无菌大鼠、小鼠和兔子中，在含有异物的子宫不育区域总是发现多形核白细胞的慢性浸润。在这些子宫的可育区域从未发现多形核白细胞。大鼠子宫中的异物，可能还有小鼠子宫中的异物，与细菌感染有关，这种感染将炎症反应扩散到含有异物的子宫角，并在小鼠中偶尔也扩散到对照子宫角。从含有异物的兔子子宫角中培养不出细菌。在无菌大鼠中，多形核白细胞向子宫内的浸润和生育能力与常规大鼠中观察到的情况有显著差异。在常规大鼠中，含有小异物的子宫角全长都会出现炎症和不育，而在无菌大鼠中，炎症和不育与异物的位置密切相关。通过测量大鼠和兔子子宫腔中的溶菌酶判断，多形核白细胞将其内容物释放到子宫腔溶液中。得出的结论是，多形核白细胞衍生的某些物质可能对受精卵或精子产生毒性作用，从而导致含有异物的子宫不育。
