对来自胎儿、新生儿和成人肝脏以及肿瘤组织的分离线粒体进行的形态学和生化研究。
Morphological and biochemical studies of isolated mitochondria from fetal, neonatal, and adult liver and from neoplastic tissues.
作者信息
Mintz H A, Yawn D H, Safer B, Bresnick E, Liebelt A G, Blailock Z R, Rabin E R, Schwartz A
出版信息
J Cell Biol. 1967 Aug;34(2):513-23. doi: 10.1083/jcb.34.2.513.
Abstract
A combined morphological and biochemical investigation of mitochondria from developing and rapidly growing tissues ( tumors, fetal, and very early neonatal rat liver) revealed mitochondria which were deficient in respiratory control, showed no valinomycin induced K(+) accumulation or spontaneous Ca(++) uptake, and were unable to undergo a swelling-contraction cycle. Electron microscopic examination of fetal and neonatal livers and a mammary tumor revealed mitochondria which differed from controls with respect to matrix density and ability to undergo reversible structural changes. The importance of isolation and assay media in interpretation of results is emphasized.
摘要
对发育中和快速生长组织（肿瘤、胎儿及极早期新生大鼠肝脏）中的线粒体进行的形态学与生物化学联合研究发现，这些线粒体呼吸控制功能不足，未表现出缬氨霉素诱导的钾离子蓄积或自发的钙离子摄取，且无法经历肿胀-收缩循环。对胎儿和新生大鼠肝脏以及一个乳腺肿瘤进行的电子显微镜检查发现，线粒体在基质密度和经历可逆结构变化的能力方面与对照不同。强调了分离和测定介质在结果解释中的重要性。
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