肽合成中的副反应。V.混合酸酐法的重新审视。
Side reactions in peptide synthesis. V.A reexamination of the mixed anhydride method.
作者信息
Bodanszky M, Tolle J C
出版信息
Int J Pept Protein Res. 1977 Nov;10(5):380-4.
PMID:604287
Abstract
Acylation of amino acid beta-naphthylamides with protected (Boc) amino acidisobutylcarbonic acid mixed anhydrides resulted in each case in the formation of some undesired by-product: an isobutyloxycarbonylamino acid beta-naphthylamide. The amount of this second acylation product was particularly high, with the hindered amino acids valine and isoleucine as carboxyl-components. The nature of the amino component had no major influence on the extent of this side reaction.
摘要
氨基酸β-萘酰胺与受保护的（叔丁氧羰基）氨基酸异丁基碳酸混合酸酐进行酰化反应，每种情况下都会生成一些不需要的副产物：异丁氧基羰基氨基酸β-萘酰胺。这种第二种酰化产物的量特别高，尤其是当带有位阻的氨基酸缬氨酸和异亮氨酸作为羧基成分时。氨基成分的性质对这种副反应的程度没有重大影响。
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