2,3-二磷酸甘油酸对人血红蛋白氧解离曲线的影响。
The effect of 2,3-diphosphoglycerate on the oxygen dissociation curve of human haemoglobin.
作者信息
Goodford P J, Norrington F E, Paterson R A, Wootton R
出版信息
J Physiol. 1977 Dec;273(3):631-45. doi: 10.1113/jphysiol.1977.sp012114.
Abstract
- Oxygen dissociation curves for concentrated human haemoglobin solutions (1.6 mmol dm-3 in haem) have been measured by mixing known quantities of oxy- and deoxyhaemoglobin solutions and measuring the resulting partial pressure of oxygen with an oxygen electrode. 2. Observations in the presence of 2,3-diphosphoglycerate support previous conclusions derived from experiments at low haemoglobin concentrations, the validity of which has been questioned. 3. The two affinity state model of Monod, Wyman & Changeux (1965) does not fully describe the actions of 2,3-diphosphoglycerate and a model in which this allosteric effector not only binds preferentially to the T state but also lowers the oxygen affinity of this state gives an improved fit to the data.
摘要
- 通过混合已知量的氧合血红蛋白溶液和脱氧血红蛋白溶液，并使用氧电极测量所得的氧分压，已测定了浓缩人血红蛋白溶液（血红蛋白浓度为1.6 mmol dm⁻³）的氧解离曲线。2. 在2,3-二磷酸甘油酸存在下的观察结果支持了先前从低血红蛋白浓度实验得出的结论，而这些结论的有效性曾受到质疑。3. 莫诺、怀曼和尚热（1965年）提出的双亲和态模型不能完全描述2,3-二磷酸甘油酸的作用，而一个模型表明这种变构效应剂不仅优先结合到T态，还降低了该状态的氧亲和力，此模型能更好地拟合数据。
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