Lussier A, de Medicis R
J Rheumatol. 1977 Winter;4(4):369-76.
To study the mechanism by which oxonate-induced hyperuricemia inhibits the development of adjuvant arthritis in the rat, we initiated blocking or releasing experiments by changing the oxonate diet of rats at selected times. We were able to define oxonate dietary effects on four specific periods in the development of this experimental arthritis. The inhibition of the primary inflammation at the site of the injection was weak. The inhibition of the secondary reaction was greater than the decrease of the primary inflammation and was more effective when the first two periods (sensitization to antigen and production of immunocompetent cells) were blocked. The reduction in the disease was more marked in the non-injected paw than in the injected paw. Thus, the effect of the oxonate diet is more immunosuppressive than anti-inflammatory. Release of the first period, which provoked an unexpected increase in the severity of the disease, suggests a possible influence of oxonate on pyrimidine metabolism.
为研究氧嗪酸钾诱导的高尿酸血症抑制大鼠佐剂性关节炎发展的机制，我们通过在选定时间改变大鼠的氧嗪酸钾饮食启动了阻断或释放实验。我们能够确定氧嗪酸钾饮食对这种实验性关节炎发展的四个特定时期的影响。对注射部位原发性炎症的抑制作用较弱。继发性反应的抑制作用大于原发性炎症的减轻，并且在前两个时期（对抗原的致敏和免疫活性细胞的产生）被阻断时更有效。疾病在未注射的爪子上的减轻比在注射的爪子上更明显。因此，氧嗪酸钾饮食的作用更多是免疫抑制而非抗炎。释放第一个时期，这引发了疾病严重程度意外增加，提示氧嗪酸钾可能对嘧啶代谢有影响。
