Bernard P A
J Otolaryngol. 1977 Dec;6(6):509-18.
Correlations are made between the electrocochleographic aspects and the ultrastructural findings in 60 guinea pigs intoxicated with either Gentamycin or Tobramycin. Small cochlear lesions are studied in order to identify the electrical aspect corresponding to the earliest anatomical cell alterations. The wave shape seems to be more important than the classical input-output functions as first signs of the inability of the organ of Corti to clear the aminoside antibiotics. The reversal of N1 and N2 and later the accentuation of P1, frequently correspond to early signs of cell intoxication such as disruption of the regular arrangement of the endoplasmic reticulum and proliferation of lysosomes. A similar situation may obtain in humans intoxicated with aminosides.
对60只分别用庆大霉素或妥布霉素中毒的豚鼠的耳蜗电图特征与超微结构结果进行了相关性研究。对小的耳蜗病变进行研究，以确定与最早的解剖学细胞改变相对应的电特征。作为柯蒂氏器清除氨基糖苷类抗生素能力丧失的最初迹象，波形似乎比经典的输入-输出功能更为重要。N1和N2的反转以及随后P1的增强，常常对应于细胞中毒的早期迹象，如内质网规则排列的破坏和溶酶体的增殖。在氨基糖苷类中毒的人类中可能也会出现类似情况。
