肾上腺髓质的脂质。溶血卵磷脂，嗜铬颗粒的一种特征性成分。
Lipids of the adrenal medulla. Lysolecithin, a characteristic constituent of chromaffin granules.
作者信息
Blaschko H, Firemark H, Smith A D, Winkler H
出版信息
Biochem J. 1967 Aug;104(2):545-9. doi: 10.1042/bj1040545.
Abstract
- The lipid composition of microsomes, mitochondria and chromaffin granules, obtained from homogenates of bovine adrenal medulla, has been investigated. 2. The three types of particle showed characteristic differences of phospholipid and cholesterol content. The lipid composition of microsomes and mitochondria resembled that of corresponding particles from other tissues. The chromaffin granules contained 19% of the cholesterol and 14% of the phospholipids of the low-speed supernatant. 3. Thin-layer chromatography indicated the presence of these phospholipids in extracts from each particle: lecithin, lysolecithin, phosphatidylethanolamine (partly plasmalogen), phosphatidylserine, phosphatidylinositol and sphingomyelin. 4. On quantitative analysis of the phospholipids, chromaffin granules were found to contain a high concentration of lysolecithin (17% of the lipid phosphorus). Mitochondria and microsomes, on the other hand, contained very little lysolecithin (less than 2% of the lipid phosphorus).
摘要
- 对从牛肾上腺髓质匀浆中获得的微粒体、线粒体和嗜铬颗粒的脂质组成进行了研究。2. 这三种类型的颗粒在磷脂和胆固醇含量上表现出特征性差异。微粒体和线粒体的脂质组成与其他组织中相应颗粒的脂质组成相似。嗜铬颗粒含有低速上清液中19%的胆固醇和14%的磷脂。3. 薄层色谱法表明，每种颗粒提取物中都存在这些磷脂：卵磷脂、溶血卵磷脂、磷脂酰乙醇胺（部分为缩醛磷脂）、磷脂酰丝氨酸、磷脂酰肌醇和鞘磷脂。4. 对磷脂进行定量分析时，发现嗜铬颗粒含有高浓度的溶血卵磷脂（占脂质磷的17%）。另一方面，线粒体和微粒体中溶血卵磷脂含量极少（占脂质磷的不到2%）。
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