5-碘-2'-脱氧尿苷对细胞培养中B病毒的抑制作用。
Inhibition of B virus in cell culture by 5-iodo-2'-deoxyuridine.
作者信息
Miller F A
出版信息
Appl Microbiol. 1967 Jul;15(4):733-5. doi: 10.1128/am.15.4.733-735.1967.
Abstract
The antimetabolite 5-iodo 2'-deoxyuridine (IDU) interferes with B virus replication in monolayers of cynomolgous monkey kidney, KB and HEp 2 cells. To determine the effect of this clinically active nucleoside in laboratory antiviral screening systems, several methods were compared. Most of the methods used were capable of detecting the activity of IDU at low levels.
摘要
抗代谢物5-碘-2'-脱氧尿苷（IDU）可干扰食蟹猴肾单层细胞、KB细胞和HEp 2细胞中的B病毒复制。为了在实验室抗病毒筛选系统中确定这种具有临床活性的核苷的作用，对几种方法进行了比较。所使用的大多数方法都能够检测到低水平的IDU活性。
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