Macri J N, Weiss R R, Tillitt R, Balsam D, Elligers K W
JAMA. 1976 Sep 13;236(11):1251-4.
A prospective program for the prenatal detection of neural tube defects in a high-risk pregnancy group has been under way for one year. Twenty high-risk mothers have undergone a complete prenatal work-up, including sonography, amniocentesis, and amniotic fluid and maternal serum alpha-fetoprotein quantitation. Within this group, two cases were prospectively diagnosed and were later confirmed.
一项针对高危妊娠组神经管缺陷产前检测的前瞻性项目已开展一年。二十位高危孕妇接受了全面的产前检查，包括超声检查、羊膜穿刺术以及羊水和母血清甲胎蛋白定量检测。在该组中，有两例被前瞻性诊断出，随后得到了证实。
