兔肾中尿酸盐分泌与对氨基马尿酸盐分泌之间的关系。
The relation between secretion of urate and p-aminohippurate in the rabbit kidney.
作者信息
Moller J V
出版信息
J Physiol. 1967 Sep;192(2):505-17. doi: 10.1113/jphysiol.1967.sp008312.
Abstract
- The renal excretion of urate in the rabbit was examined during infusion of other anions which are secreted by the kidney. A reduction of urate excretion occurred after administration of p-aminohippurate (PAH) and Diodrast which was proportional to the secretory rate of these compounds. On the other hand, urate was a less efficient inhibitor of PAH secretion.2. Stop-flow experiments showed that tubular secretion of urate at maximal values for secretion of PAH and Diodrast was almost completely suppressed.3. 2,4-Dinitrophenol, fumarate, succinate, salicylate, and probenecid depressed the excretion of urate and PAH, but the tubular secretion of urate was apparently more depressed than that of PAH by these inhibitors.4. It is concluded that a common transport system for urate and PAH is involved in the tubular secretion of urate and PAH in the rabbit. However, the affinity of urate for the transport system appears to be smaller than that of PAH.
摘要
在输注由肾脏分泌的其他阴离子期间，对家兔尿酸盐的肾排泄情况进行了检查。给予对氨基马尿酸（PAH）和碘司特后，尿酸盐排泄减少，且减少程度与这些化合物的分泌速率成正比。另一方面，尿酸盐对PAH分泌的抑制作用较弱。
停流实验表明，在PAH和碘司特分泌达到最大值时，尿酸盐的肾小管分泌几乎完全受到抑制。
2,4-二硝基苯酚、富马酸盐、琥珀酸盐、水杨酸盐和丙磺舒可降低尿酸盐和PAH的排泄，但这些抑制剂对尿酸盐肾小管分泌的抑制作用明显比对PAH的抑制作用更强。
得出的结论是，尿酸盐和PAH的肾小管分泌涉及一种共同的转运系统。然而，尿酸盐对该转运系统的亲和力似乎小于PAH。
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