离子对心肌肌浆网钙蓄积的影响。
Ion effects on calcium accumulation by cardiac sarcoplasmic reticulum.
作者信息
Palmer R F, Posey V A
出版信息
J Gen Physiol. 1967 Sep;50(8):2085-95. doi: 10.1085/jgp.50.8.2085.
Abstract
The effects of monovalent cations on the active calcium-accumulating ability of cardiac sarcoplasmic reticulum were assessed. Grana prepared in an ion-free system accumulated calcium when ATP and Mg(++) were present. Sodium ion and to a lesser extent lithium but not K(+) reduced the amount of calcium taken up. The reduction of calcium binding by Na(+) is not due to inhibition of uptake but to a rapid release of the radiocalcium bound. The amount of calcium released by sodium does not appear to be enough to explain contraction on the basis of sodium influx into muscle, but may be significant in the regulation of tension.
摘要
评估了单价阳离子对心肌肌浆网主动钙积累能力的影响。在无离子体系中制备的微粒体在存在ATP和Mg(++)时积累钙。钠离子以及程度稍轻的锂离子可降低钙的摄取量，但钾离子无此作用。钠离子对钙结合的降低并非由于摄取受抑制，而是由于已结合的放射性钙的快速释放。钠释放的钙量似乎不足以解释基于钠流入肌肉而产生的收缩，但可能在张力调节中具有重要意义。
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