钠和钾对肌浆网囊泡中钙转运的钙离子依赖性抑制作用。
Ca-2+-dependent inhibitory effects of Na+ and K+ on Ca-2+ transport in sarcoplasmic reticulum vesicles.
作者信息
Gattass C R, De Meis L
出版信息
Biochim Biophys Acta. 1975 May 21;389(3):506-15. doi: 10.1016/0005-2736(75)90161-3.
Effects of Na+ and K+ on Ca-2+ transport by sarcoplasmic reticulum vesicles were studied in a medium containing high Mg-2+ and ATP (2mM) and low Ca-2+ (0.44muM) concentrations. Under these conditions, Na+ and K+ inhibit Ca-2+ uptake, ATPase activity and membrane phosphorylation by ATP. Since the concentrations of ATP and Ca-2+ used are consistent with relaxation in vivo, the results suggest that under physiological resting conditions the Ca-2+ pump of the sarcoplasmic reticulum operates below its maximal capacity.
在含有高浓度Mg²⁺和ATP（2mM）以及低浓度Ca²⁺（0.44μM）的介质中，研究了Na⁺和K⁺对肌浆网囊泡Ca²⁺转运的影响。在这些条件下，Na⁺和K⁺抑制Ca²⁺摄取、ATP酶活性以及ATP介导的膜磷酸化。由于所用的ATP和Ca²⁺浓度与体内舒张状态一致，结果表明在生理静息条件下，肌浆网的Ca²⁺泵在其最大容量以下运行。
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