El-Dessoukey E A, Awadallah R, El-Attar S
Z Ernahrungswiss. 1977 Dec;16(4):217-22. doi: 10.1007/BF02023698.
The present study deals with investigations on the general features of protein and iron metabolism under several conditions of chronic and acute liver damage induced by carbon tetrachloride. Data revealed a drop in the levels of serum total protein and albumin. The levels of alpha1, alpha2 and beta globulins were found to be increased. Gamma fraction was found to be proportionate with dosage accumulation and to varying extent. There were changes in haematocrit and haemoglobin values in all groups of chronic and acute carbon tetrachloride intoxicated rats. Also, there were no changes in reticulocyte count, plasma iron and total iron binding capacity levels in chronic intoxicated animals. However, in acute carbon tetrachloride plasma iron and total iron-binding capacity were significantly elevated.
本研究针对四氯化碳诱导的几种急慢性肝损伤情况下蛋白质和铁代谢的一般特征展开调查。数据显示血清总蛋白和白蛋白水平下降。发现α1、α2和β球蛋白水平升高。γ组分被发现与剂量累积成比例且在不同程度上有所变化。所有急慢性四氯化碳中毒大鼠组的血细胞比容和血红蛋白值均有变化。此外，慢性中毒动物的网织红细胞计数、血浆铁和总铁结合力水平没有变化。然而，急性四氯化碳中毒时血浆铁和总铁结合力显著升高。
