[抗生素联合治疗在慢性肾盂肾炎中的价值——对大量患者长达15年的研究]

[Value of antibiotic combination therapy in chronic pyelonephritis--study on a large number of patients over a period of 15 years].

Philippson C

Z Gesamte Inn Med. 1977 Dec 1;32(23):661-5.

Abstract

448 patients with chronic pyelonephritis were treated over periods ranging from a minimum of 5 to a maximum of 15 years with our special form of intermittent long-term therapy with chemoprophylaxis in the intervals, the antibiotics - mostly in the form of combinations - and chemotherapeutics in the treatment-phases were always used only on the base of several antibiograms. During the last 11 years synergistic bactericidic combinations of antibiotics were used to an increasing degree. 2. A comparison of the efficacy of our form of therapy used now (since 1965/1966) with the results already published: 1966 (therapy span 1960-1965), 1970 (therapy span 1960-1969), and 1972 (therapy span 1960-1971) showed the following quotes of a transmission into a standstill (questionable healing) of the disease: 1966 (without periodic change of the urinary pH) 36,1% 1966 (with periodic change of the urinary pH) 69,4% 1970 (synergistic combinations of antibiotics) 68,3% 1972 (synergistic combinations of antibiotics) 78,7% 1976 (synergistic combinations of antibiotics) 82,1%. 3. On the basis of our results we consider the combinations of synergistic bactericidic antibiotics as a real enrichment of the therapy of chronic pyelonephritis.

摘要

448例慢性肾盂肾炎患者接受了我们特殊形式的间歇性长期治疗，治疗期从最短5年到最长15年不等，期间进行化学预防，抗生素（大多为联合用药形式）和化疗药物仅在多次细菌药敏试验的基础上用于治疗阶段。在过去11年中，抗生素的协同杀菌联合用药的使用程度越来越高。2. 将我们目前（自1965/1966年起）使用的治疗方法的疗效与已发表的结果进行比较：1966年（治疗期为1960 - 1965年）、1970年（治疗期为1960 - 1969年）和1972年（治疗期为1960 - 1971年），结果显示疾病转为静止（可疑治愈）的比例如下：1966年（未定期改变尿液pH值）36.1%，1966年（定期改变尿液pH值）69.4%，1970年（抗生素协同联合用药）68.3%，1972年（抗生素协同联合用药）78.7%，1976年（抗生素协同联合用药）82.1%。3. 根据我们的结果，我们认为协同杀菌抗生素联合用药是慢性肾盂肾炎治疗的真正进步。