Wozniak K D
Z Gesamte Inn Med. 1977 Dec 15;32(24):676-80.
For the diagnostics of allergic drug reactions in 2,246 patients tests of the skin and in vitro tests were carried out. As causes of the drug rashes analgetics/antipyretics, antibiotics, sulfonamides, local anaesthetics, oral anticonceptive drugs, remedies for the circulation, psychopharmaca and many others have been established. In these cases by means of skin test in 81.5%, by means of the lymphocyte transformation test in 42.9% and by means of the migration inhibition test in 35.9% of the patients a concordant result could be achieved concerning the clinical course of the disease. Relevant to practice from the results must be derived that in sensibilisation proved the avoidance of the pharmacon and of immunochemical related substances is necessary as well as principally in every anamnesis the question for drug tolerances must be asked. The possibility of the development of side effects of pharmaca when these facts are not taken into consideration is emphasized with the help of examples.
对2246例患者进行了皮肤试验和体外试验以诊断药物过敏反应。已确定镇痛药/退热药、抗生素、磺胺类药物、局部麻醉药、口服避孕药、循环系统药物、精神药物等为药疹的病因。在这些病例中，通过皮肤试验，81.5%的患者、通过淋巴细胞转化试验，42.9%的患者以及通过迁移抑制试验，35.9%的患者在疾病临床过程方面可获得一致结果。从结果中得出与实践相关的结论，即在已证实致敏的情况下，必须避免使用该药物及免疫化学相关物质，并且在每次问诊时原则上都必须询问药物耐受性问题。借助实例强调了不考虑这些事实时药物出现副作用的可能性。
