[甲苯磺丁脲作为垂体生长激素分泌的刺激剂]
[Tolbutamide as a stimulator of somatotropin secretion from the hypophysis].
作者信息
Spanar E, Uhrín P, Levcík A, Záhradný V
出版信息
Z Gesamte Inn Med. 1977 Dec 15;32(24):694-5.
Our clinical experiments should point at the potential quality of tolbutamide as a stimulator of the secretion of the growth hormone. This could not be ascribed to the hypoglycaemic action of tolbutamide, because during the 240 minutes' time of the duration of the test, the glycaemic levels in the blood have been kept stabilised at the same levels as in fasting conditions before the application of tolbutamide, by a continuous intravenous drop of a 10% solution of glucose. The values of the growth hormone after application of tolbutamide raised two to fourfold in comparison to the initial value.
我们的临床试验应指向甲苯磺丁脲作为生长激素分泌刺激剂的潜在性质。这不能归因于甲苯磺丁脲的降血糖作用，因为在测试持续的240分钟内，通过持续静脉滴注10%的葡萄糖溶液，血液中的血糖水平一直维持在应用甲苯磺丁脲之前空腹状态下的相同水平。应用甲苯磺丁脲后生长激素的值相较于初始值升高了两到四倍。
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