用锝-99m 尿激酶对血栓进行显像。一份阴性报告。

Visualisation of thrombi with technetium-99m urokinase. A negative report.

作者信息

Weir G J, Wenzel F J, Roberts R C, Sautter R D

出版信息

Lancet. 1976 Aug 14;2(7981):341-2. doi: 10.1016/s0140-6736(76)92594-0.

Abstract

Direct imaging of thrombi with isotopically labelled agents would provide a convenient atraumatic method of diagnosing deep venous thrombosis. Urokinase labelled with technectium-99m has many theoretical advantages and successful use of this agent has been reported. A method for tagging urokinase with Tc-99m has been developed which preserves the clot-lysing ability of the urokinase. The thrombus imaging previously reported has not been duplicated.

摘要

使用同位素标记剂对血栓进行直接成像将为诊断深静脉血栓形成提供一种便捷的无创方法。用锝-99m标记的尿激酶具有许多理论优势，并且已有关于成功使用该试剂的报道。已经开发出一种用锝-99m标记尿激酶的方法，该方法保留了尿激酶的溶栓能力。先前报道的血栓成像尚未得到重复验证。