Gróf J, Menyhárt J
Acta Chir Acad Sci Hung. 1977;18(3):283-7.
The composition and toxicity of polypeptides prepared from normal and uraemic sera by the combination of Dowex and Sephadex column chromatography have been studied. Significant changes in composition associated with an increased toxicity and decreased diffusibility of peptides (Mwt, 1800--2500 D) isolated from uraemic sera were detected. Due to their moderate of high toxicity as well as their poor or non-diffusibility, these uraemic polypeptides are proposed to be regarded as a new group of uraemic toxins.
通过Dowex和Sephadex柱色谱法联用，对从正常血清和尿毒症血清中制备的多肽的组成和毒性进行了研究。检测到从尿毒症血清中分离出的肽（分子量为1800 - 2500道尔顿）的组成有显著变化，同时其毒性增加且扩散性降低。由于这些尿毒症多肽具有中度至高毒性以及较差的或无扩散性，因此建议将它们视为一组新的尿毒症毒素。
