Acta Neurol Scand. 1977 Dec;56(6):613-9. doi: 10.1111/j.1600-0404.1977.tb01467.x.
Four patients suffering form familial periodic paralysis with hypokalaemia (FPP) were subjected untreated to standardized induction of paralysis. The induction was repeated after pre-treatment with the beta receptor blocker propranolol (Inderal). In three of the patients propranolol had no or even a negative effect upon the development of paralysis or upon the fall in serum potassium. In one patient a slight prophylactic gain was achieved. It was not possible to demonstrate any difference in the serum level of glucose or insulin during the induction of paralysis according to whether the patients were untreated or treated with propranolol. Short-lasting out-patient treatment of the patient who had apparently had some slight prophylactic benefit from propranolol had to be discontinued after 11 days because of an unusually severe and long-lasting attack. It is concluded that propranolol has no major effect in the treatment of FPP-unlike its favourable effect in thyrotoxic familial periodic paralysis (TFPP).
对4例患有家族性低钾性周期性麻痹（FPP）的患者未进行治疗，直接进行标准化的麻痹诱导。在用β受体阻滞剂普萘洛尔（心得安）预处理后，重复进行诱导。在3例患者中，普萘洛尔对麻痹的发展或血清钾的下降没有影响，甚至有负面影响。在1例患者中，获得了轻微的预防效果。无论是未治疗的患者还是用普萘洛尔治疗的患者，在麻痹诱导期间，均未发现血糖或胰岛素血清水平有任何差异。因出现异常严重且持久的发作，接受普萘洛尔治疗后明显有轻微预防效果的1例患者，在门诊进行11天的短期治疗后不得不停药。得出的结论是，普萘洛尔在治疗FPP方面没有主要作用，这与它在甲状腺毒症性家族性周期性麻痹（TFPP）中的良好效果不同。
