甲状腺降钙素对猫灌注胫骨血-骨钙平衡的影响。
The effect of thyrocalcitonin on blood-bone calcium equilibrium in the perfused tibia of the cat.
作者信息
Macintyre I., Parsons J. A., Robinson C. J.
出版信息
J Physiol. 1967 Jul;191(2):393-405. doi: 10.1113/jphysiol.1967.sp008257.
Abstract
- In the isolated tibia of the cat, perfused with blood from its own carotid connected to popliteal artery via a pump, infusion of porcine thyrocalcitonin causes an arteriovenous difference in calcium concentration of up to 5%, corresponding to net retention of calcium in bone.2. When taken in conjunction with determinations of radiocalcium clearance in the tibia, the effect is of the right order of magnitude to account for the hypocalcaemic action of thyrocalcitonin in the whole animal.3. Calcium retention was accompanied by a small increase in acidity of outflowing venous blood whereas verification of the hypothesis of calcium regulation by pH change in the bone substance would require a decrease.
摘要
- 在猫的离体胫骨中，通过泵将来自其自身颈动脉的血液灌注到腘动脉，注入猪甲状腺降钙素会导致钙浓度的动静脉差异高达5%，这与骨中钙的净潴留相对应。2. 结合胫骨中放射性钙清除率的测定来看，这种效应的量级恰能解释甲状腺降钙素在整个动物体内的降钙作用。3. 钙潴留伴随着流出静脉血酸度的小幅增加，而要证实骨物质中pH变化调节钙的假说则需要酸度降低。
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