影响受辐照小鼠造血脾集落形成的因素。I. 内源性集落形成的正常模式。
Factors influencing hematopoietic spleen colony formation in irradiated mice. I. The normal pattern of endogenous colony formation.
作者信息
Marsh J C, Boggs D R, Bishop C R, Chervenick P A, Cartwright G E, Wintrobe M M
出版信息
J Exp Med. 1967 Nov 1;126(5):833-49. doi: 10.1084/jem.126.5.833.
Data pertaining to the endogenous mouse spleen colony system, 10 days postirradiation, are presented. The D(o) for visible colonies is 78 R, while that for 6 hr iron uptake over a range of 600-800 R is 50 R. The D(o) for spleen weight is 196 R and that for IUdR uptake is 193 R. These measurements increase with the age of the mouse. Hypertransfusion decreases spleen iron uptake and colony number. DF-(32)P and sodium sulfate-(35)S are not useful indicators of splenic hematopoiesis in this system. Visible hematopoietic colonies in the spleen are not produced by vinblastine, nitrogen mustard, methotrexate, or cyclophosphamide.
本文给出了照射后10天的内源性小鼠脾集落系统的数据。可见集落的D（o）为78伦琴，而在600 - 800伦琴范围内6小时铁摄取的D（o）为50伦琴。脾重量的D（o）为196伦琴，碘脱氧尿苷摄取的D（o）为193伦琴。这些测量值随小鼠年龄增加而升高。过度输血会降低脾铁摄取和集落数量。在该系统中，二氟磷酸 -（32）磷和硫酸钠 -（35）硫不是脾造血的有用指标。脾中的可见造血集落不是由长春碱、氮芥、甲氨蝶呤或环磷酰胺产生的。
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