1α-羟维生素D3和1,25-二羟维生素D3对糖皮质激素治疗患者肠道及骨骼的影响

Effect of 1alpha-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on intestine and bone in glucocorticoid-treated patients.

作者信息

Lund B, Andersen R B, Friis T, Hjorth L, Jørgensen F S, Norman A W, Sørensen O H

出版信息

Clin Endocrinol (Oxf). 1977 Dec;7 Suppl:177s-181s. doi: 10.1111/j.1365-2265.1977.tb03379.x.

DOI:10.1111/j.1365-2265.1977.tb03379.x

Abstract

The effect of 1alpha-hydroxyvitamin D3 (1alpha-OHD3) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the intestinal calcium absorption was studied in twenty patients with rheumatoid arthritis treated with prednisone at daily doses of 5--15 mg for 1/2--20 years. The fractional calcium absorption, measured before and after the treatment with the vitamin D compounds, increased in nineteen of the twenty patients. This was, however, accompanied by marked rises in the urinary calcium excretion. There was no correlation between the fractional calcium absorption and the duration of the prednisone treatment or the doses given.

摘要

研究了1α-羟基维生素D3（1α-OHD3）和1,25-二羟基维生素D3（1,25-(OH)2D3）对20例类风湿性关节炎患者肠道钙吸收的影响，这些患者接受泼尼松治疗，每日剂量为5-15毫克，疗程为半年至20年。在用维生素D化合物治疗前后测量的钙吸收率，在20例患者中有19例有所增加。然而，这伴随着尿钙排泄的显著增加。钙吸收率与泼尼松治疗的持续时间或给药剂量之间没有相关性。