Ohno S, Klein J, Poole J, Harris C, Destree A, Morrison M
Science. 1967 Apr 7;156(3771):96-8. doi: 10.1126/science.156.3771.96.
The isozyme patterns of lactate dehydrogenases of various tissues were studied on 51 hagfish by starch-gel electrophoresis. Nine lactate dehydrogenase phenotypes were encountered, suggesting the coexistence of two alleles at each of the two separate gene loci. There apparently was no interaction between the products of these two separate loci. Even the products of two alleles at the same locus were apparently incapable of forming hybrid molecules, an indication of the possible monomeric nature of each lactate dehydrogenase molecule.
通过淀粉凝胶电泳对51条盲鳗的各种组织中的乳酸脱氢酶同工酶模式进行了研究。共发现了9种乳酸脱氢酶表型,这表明在两个独立的基因位点上,每个位点都存在两个等位基因。这两个独立位点的产物之间显然没有相互作用。甚至同一基因座上的两个等位基因的产物显然也无法形成杂交分子,这表明每个乳酸脱氢酶分子可能具有单体性质。