Gutman L T, Wilfert C M, Idriss Z H, Schmidt E, Andrews S, Katz S L
J Infect Dis. 1977 Dec;136 Suppl:S575-8. doi: 10.1093/infdis/136.supplement_3.s575.
Ninety-two children received single doses of one of 13 monovalent vaccines derived from influenza virus strain A/New Jersey/8/76 (A/NJ), and 18 children received placebo. Five influenza virus vaccines were whole-virus vaccines, and eight were split-product vaccines. Samples of sera were taken once three weeks after vaccination. All of the 29 children receiving whole-virus vaccines developed a titer of antibody to A/NJ virus of greater than or equal to 1:20, and the geometric mean titers were 1:14-1:45. One of the 60 children who received split-product vaccines developed a titer of antibody to A/NJ of greater than or equal to 1:20, and geometric mean titers were all less than 1:10. There was a trend toward correlation between titers of hemagglutination-inhibiting (HAI) antibody to A/NJ and titers of HAI antibody to A/Victoria/3/75 viruses, with a correlation coefficient of 0.40 for children who received whole-virus vaccines. Three of 60 recipients of split-product vaccines and two of 20 recipients of whole virus developed a fever of greater than or equal to 38 C. One of the two febrile children who had received whole-virus vaccine had otitis media. Therefore, reactogenicity of whole-virus vaccines and split-product vaccines appeared to be similar in these children.
92名儿童接受了从甲型流感病毒株A/新泽西/8/76（A/NJ）衍生的13种单价疫苗中的一种的单剂量接种，18名儿童接受了安慰剂。5种流感病毒疫苗是全病毒疫苗，8种是裂解产物疫苗。接种疫苗三周后采集血清样本。接受全病毒疫苗的29名儿童均产生了抗A/NJ病毒的抗体效价大于或等于1:20，几何平均效价为1:14至1:45。接受裂解产物疫苗的60名儿童中有1名产生了抗A/NJ的抗体效价大于或等于1:20，几何平均效价均小于1:10。抗A/NJ的血凝抑制（HAI）抗体效价与抗A/维多利亚/3/75病毒的HAI抗体效价之间存在相关趋势，接受全病毒疫苗的儿童的相关系数为0.40。接受裂解产物疫苗的60名受种者中有3名以及接受全病毒疫苗的20名受种者中有2名出现了体温高于或等于38℃的发热。接受全病毒疫苗的两名发热儿童中有1名患有中耳炎。因此，在这些儿童中，全病毒疫苗和裂解产物疫苗的反应原性似乎相似。
