人体内脏对睾酮和雄烯二酮的提取与相互转化
Splanchnic extraction and interconversion of testosterone and androstenedione in man.
作者信息
Rivarola M A, Singleton R T, Migeon C J
出版信息
J Clin Invest. 1967 Dec;46(12):2095-100. doi: 10.1172/JCI105696.
A constant infusion of (3)H-testosterone and (14)C-androstenedione was administered to four human subjects, two males and two females, until the concentrations of radioactive testosterone and androstenedione in systemic plasma became constant. At that time the concentrations of radioactive testosterone and androstenedione in hepatic vein plasma were determined. Splanchnic extraction of testosterone and androstenedione and the contribution of the splanchnic system to the blood interconversion of testosterone and androstenedione were calculated. Androstenedione is extracted by the splanchnic system more efficiently than testosterone since 82.3% of androstenedione and 44% of testosterone were removed from the plasma after one passage. The fraction of testosterone entering the splanchnic system that is transferred to blood androstenedione was 0.011 and the maximum possible transfer due to recirculation was 0.026. This was 28% of the total blood transfer from testosterone to androstenedione. The fraction of androstenedione entering the splanchnic system that is transferred to blood testosterone after one passage was 0.005, whereas the maximum possible transfer in this system was 0.006. This represented only 16% of the total transfer from androstenedione to testosterone. Therefore, a large fraction of the interconversion of testosterone and androstenedione in vivo occurs outside the splanchnic system.
向四名人类受试者（两名男性和两名女性）持续输注（3）H-睾酮和（14）C-雄烯二酮，直至全身血浆中放射性睾酮和雄烯二酮的浓度达到稳定。此时测定肝静脉血浆中放射性睾酮和雄烯二酮的浓度。计算睾酮和雄烯二酮的内脏提取率以及内脏系统对睾酮和雄烯二酮血液相互转化的贡献。内脏系统对雄烯二酮的提取效率高于睾酮，因为一次通过后，82.3%的雄烯二酮和44%的睾酮从血浆中被清除。进入内脏系统并转化为血液中雄烯二酮的睾酮比例为0.011，由于再循环导致的最大可能转化率为0.026。这占睾酮向雄烯二酮总血液转化量的28%。一次通过后，进入内脏系统并转化为血液中睾酮的雄烯二酮比例为0.005，而该系统中的最大可能转化率为0.006。这仅占雄烯二酮向睾酮总转化量的16%。因此，体内睾酮和雄烯二酮的大部分相互转化发生在内脏系统之外。
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