Willard F L, Kodras R
Appl Microbiol. 1967 Sep;15(5):1014-9. doi: 10.1128/am.15.5.1014-1019.1967.
Over 170 chemical agents were screened for antiprotozoal action in bovine ruminal fluid. Compounds were tested at 0.1 and 0.05% concentrations. Tested compounds included inorganic compounds, antibiotics, biocides, neuromuscular agents, arsenicals, plant and animal hormones, antimalarials, surface-active agents, anthelmintics, and many others. The most active compounds were cupric sulfate, nickel sulfate, nitrofurazone, hydrogen peroxide, dodecyl sodium sulfate, pelargonic acid, iodoacetic acid, 1-diethylaminoethylamino-4-methylthiaxanthrone, sodium arsanilate, sodium arsenate, bismuth glycolyl arsanilate, 1-beta-hydroxyethyl-2-methyl-5-nitroimidazole, and p-nitroaniline. Copper ion was not particularly effective against entodinia; nickel ion had no effect on holotrichs. Hydrogen peroxide and iodoacetic acid were effective at a concentration of 0.005%. Anionic surface-active agents were very effective, especially long-chain sulfates and phosphates. These antiprotozoal agents warrant further in vivo studies for possible use in treating or curing bloat in ruminants.
对170多种化学试剂进行了牛瘤胃液抗原生动物作用的筛选。化合物在0.1%和0.05%的浓度下进行测试。测试的化合物包括无机化合物、抗生素、杀生物剂、神经肌肉药物、砷剂、动植物激素、抗疟药、表面活性剂、驱虫药等许多其他物质。最具活性的化合物有硫酸铜、硫酸镍、呋喃西林、过氧化氢、十二烷基硫酸钠、壬酸、碘乙酸、1-二乙氨基乙基氨基-4-甲基噻吨酮、对氨基苯胂酸钠、砷酸钠、甘氨酰对氨基苯胂酸铋、1-β-羟乙基-2-甲基-5-硝基咪唑和对硝基苯胺。铜离子对内毛虫没有特别有效的作用；镍离子对全毛目没有影响。过氧化氢和碘乙酸在0.005%的浓度下有效。阴离子表面活性剂非常有效，尤其是长链硫酸盐和磷酸盐。这些抗原生动物剂值得进一步进行体内研究，以探讨其在治疗或治愈反刍动物瘤胃臌气方面的潜在用途。
