实验性肾内反流与血压
Experimental intrarenal reflux and blood pressure.
作者信息
Moffat D B
出版信息
Br J Exp Pathol. 1977 Dec;58(6):717-24.
The effect on the blood pressure of experimental vesico-ureteric reflux was investigated in adult female Wistar rats. In 6 rats, reflux with isotonic saline produced a transient rise in systemic blood pressure followed by a fall, with return to normal within 2 min (mean BP readings: 121-130-93 mmHg). In 6 rats during water diuresis, reflux with distilled water produced similar changes (114-120-79 mmHg). In 6 rats in which the ureters were divided before reflux, no rise in blood pressure occurred although in 2 of these the pressure showed a marked fall. The pattern of blood pressure changes which occurred as a result of reflux was similar to that produced by a rapid i.v. injection of a corresponding volume of saline and it was concluded that the changes accompanying reflux are due to pyelovenous backflow. This was confirmed by producing reflux with 5% lissamine green which appeared in the peripheral capillaries within 4 s of the reflux in 3 rats. Slow dilatation of the pelvis with saline in 9 rats showed that rupture of the pelvic epithelium occurred at a mean pressure of 99 mmHg.
研究了实验性膀胱输尿管反流对成年雌性Wistar大鼠血压的影响。在6只大鼠中，用等渗盐水进行反流导致全身血压短暂升高，随后下降，2分钟内恢复正常（平均血压读数：121 - 130 - 93 mmHg）。在6只处于水利尿状态的大鼠中，用蒸馏水进行反流产生了类似的变化（114 - 120 - 79 mmHg）。在6只反流前输尿管已被切断的大鼠中，血压未升高，不过其中2只血压出现明显下降。反流导致的血压变化模式与快速静脉注射相应体积盐水所产生的模式相似，得出的结论是，反流伴随的变化是由于肾盂静脉逆流。给3只大鼠用5%丽丝胺绿进行反流，反流后4秒内外周毛细血管中出现了该染料，从而证实了这一点。用盐水对9只大鼠的肾盂进行缓慢扩张显示，肾盂上皮破裂时的平均压力为99 mmHg。
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