Wallgren A, de Schryver A, Wasserman J
Bull Cancer. 1977;64(4):627-31.
The 4 year results of a prospective clinical trial on the treatment of operable breast cancer, comparing the effects of preoperative radiotherapy followed by surgery with those of surgery followed or not by postoperative radiotherapy are presented for patient groups of approximately 100 each. At 4 years 85 per cent survive after preoperative radiotherapy plus surgery, as against 77 per cent after surgery only and 81 per cent after surgery plus postoperative radiotherapy. These differences are not statistically significant. The incidence of local recurrence after radiotherapy was reduced to 1/4 of that seen after surgery only. The radiation could be shown to induce temporary damage in a number of immunological parameters. No correlation could be demonstrated between these findings and the clinical course of the disease.
本文给出了一项针对可手术乳腺癌治疗的前瞻性临床试验的4年结果，该试验对术前放疗后手术与术后放疗或不放疗的手术效果进行了比较，每组患者约100例。4年后，术前放疗加手术组的生存率为85%，单纯手术组为77%，手术加术后放疗组为81%。这些差异无统计学意义。放疗后局部复发率降至单纯手术后的1/4。放疗可导致一些免疫参数出现暂时损伤。这些发现与疾病的临床进程之间未显示出相关性。
