Lickrish G M, Fortier M
Can Med Assoc J. 1977 Mar 19;116(6):641-3.
In a prospective trial cryotherapy was performed in 164 patients with preinvasive cervical neoplasia, most of whom desired future childbearing. Their disease had been evaluated by repeat cytology, colposcopy and colposcopically directed punch biopsies, with endocervical curettage when necessary. This conservative treatment eradicated the disease in 147 (89.6%) of the patients. The remaining 17 underwent complete reinvestigation. The focal residual disease in 12 was successfully treated by conservative means--repeat cryotherapy, focal electrocautery or punch biopsy. The other five required either cone biopsy or hysterectomy because of more extensive lesions.
在一项前瞻性试验中，对164例宫颈原位癌患者实施了冷冻疗法，其中大多数患者希望未来生育。通过重复细胞学检查、阴道镜检查以及阴道镜引导下的咬取活检对其病情进行了评估，必要时还进行了宫颈管刮除术。这种保守治疗使147例（89.6%）患者的疾病得到根除。其余17例患者接受了全面复查。12例患者的局灶性残留病变通过保守方法成功治疗——重复冷冻疗法、局灶性电灼或咬取活检。另外5例患者因病变范围更广，需要进行锥形活检或子宫切除术。
