Tornberg D N, Bassett C A
Clin Orthop Relat Res. 1977 Nov-Dec(129):305-12. doi: 10.1097/00003086-197711000-00043.
A single para osteal injection of an aqueous extract of immature bovine bone doubles the diameter of the rat radius and ulna, within 7 days. Bone is formed by activation and prolifeation of cells in the cambium layer of the periosteum. The fibrous periosteum remains intact and appears to adapt by stretching. New trabeculae are oriented radailly about the diphyses. The organic matrix, mainly new bone collagen is elaborated primarly during the first 72 hours and mineralized, in the last 4 days of study. The response is interpreted as an example of cell activation, rather than osteogenic induction and demonstrates tha rapid and massive osteogensis can be trigegered by an appropriate exogenous stimulus.
单次骨膜下注射未成熟牛骨水提取物可在7天内使大鼠桡骨和尺骨直径增加一倍。骨是由骨膜形成层中的细胞活化和增殖形成的。纤维性骨膜保持完整，似乎通过伸展来适应。新的小梁围绕骨干呈放射状排列。有机基质，主要是新骨胶原蛋白，主要在最初的72小时内形成，并在研究的最后4天矿化。这种反应被解释为细胞活化的一个例子，而不是成骨诱导，并表明适当的外源性刺激可以引发快速而大量的成骨。
