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Effect of NDGA, a lipoxygenase inhibitor, on prolactin actions in mouse mammary gland explants.

作者信息

Rillema J A

出版信息

Prostaglandins Leukot Med. 1984 Oct;16(1):89-94. doi: 10.1016/0262-1746(84)90089-1.

DOI:10.1016/0262-1746(84)90089-1
PMID:6083569
Abstract

Nordihydroguaiaretic acid (NDGA) at a concentration of 50 microM abolished the actions of prolactin on RNA, casein and lipid biosynthesis in cultured mouse mammary gland explants. NDGA at 100 microM also reduced the magnitude of the prolactin stimulation of ornithine decarboxylase activity. Since NDGA is known to be an inhibitor of lipoxygenase activity, we would conclude that ongoing leukotriene synthesis may be essential for prolactin to express at least certain of its lactogenic actions in the mammary gland.

摘要

相似文献

1
Effect of NDGA, a lipoxygenase inhibitor, on prolactin actions in mouse mammary gland explants.
Prostaglandins Leukot Med. 1984 Oct;16(1):89-94. doi: 10.1016/0262-1746(84)90089-1.
2
Effect of 3-isobutyl-1-methylxanthine on prolactin actions on RNA synthesis, casein synthesis, lipid synthesis and ornithine decarboxylase activity in mouse mammary gland explants.3-异丁基-1-甲基黄嘌呤对催乳素在小鼠乳腺外植体中RNA合成、酪蛋白合成、脂质合成及鸟氨酸脱羧酶活性作用的影响。
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Effect of kinase C inhibitor, gossypol, on the actions of prolactin in cultured mouse mammary tissues.
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Phorbol myristate acetate stimulates RNA and casein synthesis in cultured mouse mammary gland tissues.佛波醇肉豆蔻酸酯乙酸盐刺激培养的小鼠乳腺组织中的RNA和酪蛋白合成。
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Early action of prolactin on ornithine decarboxylase activity is not essential for the subsequent actions of prolactin on casein and lipid biosynthesis.催乳素对鸟氨酸脱羧酶活性的早期作用对于催乳素随后对酪蛋白和脂质生物合成的作用并非必不可少。
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Prolactin actions on casein and lipid biosynthesis in mouse and rabbit mammary gland explants are abolished by p-bromphenacyl bromide and quinacrine, phospholipase A2 inhibitors.
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Effect of various concentrations of prolactin and growth hormone on the magnitude of stimulation of RNA synthesis, casein synthesis and ornithine decarboxylase activity in mouse mammary gland explants.不同浓度的催乳素和生长激素对小鼠乳腺外植体中RNA合成、酪蛋白合成及鸟氨酸脱羧酶活性刺激程度的影响。
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Regulation of casein synthesis by polyamines in mammary gland explants of mice.多胺对小鼠乳腺外植体中酪蛋白合成的调控
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Extracellular calcium ion concentration required for prolactin to express its actions on casein, ribonucleic acid, and lipid biosynthesis in mouse mammary gland explants.催乳素对小鼠乳腺外植体中酪蛋白、核糖核酸和脂质生物合成发挥作用所需的细胞外钙离子浓度。
Endocrinology. 1983 Nov;113(5):1596-600. doi: 10.1210/endo-113-5-1596.
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[Effect of aspirin and nordihydroguaiaretic acid on the secretion of milk caseins by the mammary epithelial cell].[阿司匹林和去甲二氢愈创木酸对乳腺上皮细胞酪蛋白分泌的影响]
Reprod Nutr Dev (1980). 1986;26(2B):575-82.

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