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脓毒性休克中的急性胃黏膜溃疡形成。发病机制的实验研究

Acute gastric mucosal ulceration in septic shock. An experimental study on pathogenic mechanisms.

作者信息

Arvidsson S, Fält K, Haglund U

出版信息

Acta Chir Scand. 1984;150(7):541-7.

PMID:6083689
Abstract

Intravenous infusion of live. E. coli bacteria in cats did not induce microscopic damage to the gastric mucosa within 3 hours. However, if the cats before the induction of bacteremia were given 80 mM HCl and 0.6 ml gallbladder bile/kg b.w. microscopic mucosal damage developed regularly in the corpus-fundus area of the stomach. The gastric mucosal damage was not associated with significant decrease of total gastric blood flow as measured continuously electromagnetically or decreased gastric mucosal blood flow measured early and late during sepsis using radioactively labelled microspheres. Neither was the development of gastric mucosal damage associated with reduced gastric wall collagen concentration nor in RNA, DNA concentrations or RNA/DNA ratio in the gastric mucosa.

摘要

给猫静脉注射活的大肠杆菌,在3小时内未引起胃黏膜的微观损伤。然而,如果在诱导菌血症之前给猫每千克体重注射80 mM盐酸和0.6毫升胆囊胆汁,胃体-胃底区域会定期出现微观黏膜损伤。胃黏膜损伤与通过电磁连续测量的总胃血流量显著减少无关,也与使用放射性标记微球在脓毒症早期和晚期测量的胃黏膜血流量减少无关。胃黏膜损伤的发生也与胃壁胶原蛋白浓度降低无关,与胃黏膜中的RNA、DNA浓度或RNA/DNA比值降低也无关。

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Acute gastric mucosal ulceration in septic shock. An experimental study on pathogenic mechanisms.脓毒性休克中的急性胃黏膜溃疡形成。发病机制的实验研究
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On the pathogenesis of acute gastric mucosal lesions in septic shock.脓毒性休克时急性胃黏膜病变的发病机制
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引用本文的文献

1
Gastric mucosal damage in sepsis--effects of pretreatment with a synthetic prostaglandin E1 analogue.脓毒症时的胃黏膜损伤——合成前列腺素E1类似物预处理的作用
Gut. 1985 Oct;26(10):1025-31. doi: 10.1136/gut.26.10.1025.