抗病毒核苷2'-氟-1-β-D-阿拉伯呋喃糖基嘧啶和（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的单磷酸盐与非洲绿猴肾细胞、单纯疱疹病毒1型和2型胸苷酸激酶相互作用的动力学
Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.
作者信息
Chen M S, Amico L A, Speelman D J
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):778-80. doi: 10.1128/AAC.26.5.778.
Abstract
The affinities of the monophosphates of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosyluracil and its 5-methyl analog for cellular thymidylate kinase were two or more orders of magnitude greater than for the thymidine-thymidylate kinases from herpes simplex virus types 1 and 2. In contrast, the monophosphate of (E)-5-(2-bromovinyl)-2'-deoxyuridine was found to have a higher affinity for the viral enzymes than for the cellular enzyme.
摘要
2'-氟-5-碘-1-β-D-阿拉伯呋喃糖基尿嘧啶及其5-甲基类似物的单磷酸盐对细胞胸苷酸激酶的亲和力比对单纯疱疹病毒1型和2型的胸苷-胸苷酸激酶的亲和力高两个或更多个数量级。相比之下，发现（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的单磷酸盐对病毒酶的亲和力比对细胞酶的亲和力更高。
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Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.抗病毒核苷2'-氟-1-β-D-阿拉伯呋喃糖基嘧啶和（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的单磷酸盐与非洲绿猴肾细胞、单纯疱疹病毒1型和2型胸苷酸激酶相互作用的动力学
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本文引用的文献
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Incorporation of metabolites of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues.2'-氟-5-碘-1-β-D-阿拉伯呋喃糖基胞嘧啶代谢产物掺入肿瘤和正常哺乳动物组织的脱氧核糖核酸中。
Biochem Pharmacol. 1982 Mar 15;31(6):1103-8. doi: 10.1016/0006-2952(82)90349-5.
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Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.1-(2-氟-2-脱氧-β-D-阿拉伯呋喃糖基)-5-碘胞嘧啶和-胸腺嘧啶单独及与阿昔洛韦和阿糖腺苷联合对脑内感染单纯疱疹病毒小鼠的治疗活性
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Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.1-（2'-氟-2'-脱氧-β-D-阿拉伯呋喃糖基）胸腺嘧啶在细胞培养物和兔眼中对单纯疱疹病毒的活性
Antimicrob Agents Chemother. 1983 Jun;23(6):808-13. doi: 10.1128/AAC.23.6.808.
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Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG).胸苷激酶激活作用及2'-去甲-2'-脱氧鸟苷（2'NDG）的强效抗疱疹活性。
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6
A new nucleoside analog, 9-[[2-hydroxy-1-(hydroxymethyl)ethoxyl]methyl]guanine, highly active in vitro against herpes simplex virus types 1 and 2.一种新的核苷类似物，9-[[2-羟基-1-(羟甲基)乙氧基]甲基]鸟嘌呤，在体外对1型和2型单纯疱疹病毒具有高度活性。
Antimicrob Agents Chemother. 1982 Jul;22(1):55-61. doi: 10.1128/AAC.22.1.55.
7
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