Tatarchenko I P, Oleĭnikov V E, Zhivotovskaia G G, Malinovskaia L I
Kardiologiia. 1984 Dec;24(12):51-5.
The efficacy of antiarrhythmic therapy with trimecain in 5 different regimens was studied in 87 patients, in 146 episodes of various disorders of the cardiac rhythm. On the basis of clinical and experimental (on 14 dogs with ventricular arrhythmia) studies, different schemes of trimecain treatment are compared. It was shown that combination of the intravenous and the subsequent intramuscular administration of trimecain to treat ventricular extrasystole complicating the course of acute myocardial infarction is as effective as prolonged instillation but exerts a longer action and is better tolerated by patients. Using tetrapolar chest rheography the effect of trimecain infused in the maximum single dose on the central hemodynamics and the ECG was studied in subjects without any cardiovascular pathology. It has been established that trimecain does not suppress myocardial contractility and has no hypotensive action.
对87例患者出现的146次各种心律失常发作，研究了曲美卡因5种不同给药方案的抗心律失常疗效。在临床和实验（对14只患室性心律失常的犬）研究的基础上，比较了曲美卡因不同的治疗方案。结果表明，静脉注射随后肌肉注射曲美卡因治疗急性心肌梗死病程中并发的室性期前收缩，与长时间滴注同样有效，但作用时间更长，且患者耐受性更好。在无任何心血管病变的受试者中，使用四极胸壁血流图研究了最大单次剂量输注曲美卡因对中心血流动力学和心电图的影响。已证实曲美卡因不抑制心肌收缩力，也无降压作用。
