[The detection of antibodies against D-penicillamine. 1. Coupling of D-penicillamine to various carriers and generation of antibodies against D-penicillamine conjugate].

D-Penicillamin as 2-substituted 5,5-Dimethyl-thiazolidine-4-carbonic acid has been bound to poly-L-lysin, human serum albumin and bovine gamma globulin by means of a water-soluble carbodiimid. The anti-bodies generated at animal tests by immunization of guinea pigs had been proved by means of the radial immune diffusion acc. to Ouchterlony [10].