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[脑膜炎奈瑟菌的种内交叉反应抗原。II. 不同形式脑膜炎球菌感染中针对交叉反应抗原的抗脑膜炎球菌抗体的动态变化]

[Cross-reacting intraspecies antigens of Neisseria meningitidis. II. The dynamics of antimeningococcal antibodies to cross-reacting antigens in different forms of meningococcal infection].

作者信息

Martynov Iu V, Gracheva A M, Samsonova I M, Mol'kova L Sh, Petina G K

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1984 Nov(11):60-5.

PMID:6084377
Abstract

The presence of antibodies to meningococci has been determined in the sera of 203 patients with meningococcal infection and 234 healthy persons by means of the indirect hemagglutination tests with the use of polyvalent erythrocyte diagnosticum. The tests have shown that antibodies to cross-reacting antigens can be detected both in patients with generalized forms of meningococcal infection and in healthy persons; the level and occurrence of these antibodies depend on the age of the subjects under examination and the form taken by the course of meningococcal infection. The study has revealed that the background level of antibodies to meningococci in healthy persons is mainly formed due to meningococcal carriership. Antibodies to cross-reacting meningococcal antigens have been shown to be capable of being transferred transplacentally.

摘要

采用多价红细胞诊断制剂通过间接血凝试验,在203例脑膜炎球菌感染患者和234名健康人的血清中测定了抗脑膜炎球菌抗体。试验表明,在全身性脑膜炎球菌感染患者和健康人中均可检测到针对交叉反应抗原的抗体;这些抗体的水平和出现情况取决于受检者的年龄以及脑膜炎球菌感染病程的形式。研究发现,健康人抗脑膜炎球菌抗体的基础水平主要是由于脑膜炎球菌携带状态形成的。已证明针对交叉反应性脑膜炎球菌抗原的抗体能够经胎盘转移。

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