Melita P, Gorgone S, Labruto G, Belnome N A, Palmeri R, Liotta G
Chir Ital. 1983 Oct;35(5):623-33.
The authors, after explaining why they were persuaded to effect a study about the immunological outline of patients in geriatric age, suffering from colorectal carcinoma in different stages, state the methods they adopted for the in vivo and in vitro study of the cellular and humoral immunity. In order to better characterize these subjects, the authors also dosed tumoral markers, specific enough for the large intestine carcinoma, such as CEA and AFP. After reporting the results of their research, the authors, as a conclusion, assert there is certainly a straight correlation between immunity faults, bound to ageing, and neoplastic disease; therefore, the study of the immunological outline in aged patients is very useful, not only for prognostic purposes, but also to monitoring the immunitary state, mot inclined to meet depression in such patients as a consequence of the different therapies performed.
作者在解释了他们为何被说服开展一项关于不同阶段老年结直肠癌患者免疫概况的研究后,阐述了他们在体内和体外对细胞免疫和体液免疫进行研究所采用的方法。为了更好地描述这些受试者的特征,作者还检测了对大肠癌具有足够特异性的肿瘤标志物,如癌胚抗原(CEA)和甲胎蛋白(AFP)。在报告了他们的研究结果后,作者作为结论断言,与衰老相关的免疫缺陷和肿瘤疾病之间肯定存在直接关联;因此,对老年患者免疫概况的研究非常有用,不仅有助于预后判断,还能监测免疫状态,这类患者不太容易因所进行的不同治疗而出现抑郁情绪。